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Hemoglobin
international journal for hemoglobin research
Volume 40, 2016 - Issue 2
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Short Communication

Hb Agenogi [β90(F6)Glu→Lys (GAG>AAG) HBB: c.271G>A)] in a Pregnant Thai Woman

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Pages 134-137 | Received 03 Nov 2015, Accepted 03 Dec 2015, Published online: 10 Feb 2016
 

Abstract

Hb Agenogi [β90(F6)Glu→Lys (GAG>AAG) HBB: c.271G>A)] is a very rare β-globin chain variant. We report for the first time this hemoglobinopathy in a pregnant 20-year-old Thai woman. She was seen by an obstetrician at her 14th week of gestation. She was pale and had an inflammatory lesion of her lower left leg. The hemoglobin (Hb) analysis by high performance liquid chromatography (HPLC) and low pressure liquid chromatography (LPLC) showed a peak of abnormal Hb at the C window. On capillary electrophoresis (CE), the abnormal Hb peak was observed at electrophoretic zone 4 that corresponded to the Hb E (HBB: c.79G>A) peak. Direct DNA sequencing revealed a GAG>AAG mutation at codon 90 of the β-globin gene. Thus, even though Hb Agenogi is very rare, it can be found in Thai people. The knowledge and understanding of this hemoglobinopathy will be used to assist in diagnosis, management and counseling for patients.

Acknowledgments

The authors thank the technicians at Chiang Rai Prachanukroh Hospital, Chiang Rai, Thailand for their help and assistance. We are also grateful to Kallayanee Rock, the AMS Clinical Service Center, Chiang Mai University, Chiang Mai, Thailand for refinement of the English language.

Declaration of interest

This study was supported by a grant from the University of Phayao, Phayao, Thailand. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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