Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 40, 2016 - Issue 3
137
Views
2
CrossRef citations to date
0
Altmetric
Short Communication

Spectrum of Common α-Globin Deletion Mutations in the Southern Region of Vietnam

, &
Pages 206-207 | Received 19 Feb 2016, Accepted 04 Mar 2016, Published online: 27 Apr 2016
 

Abstract

The common deletion mutations of α-globin genes in the Vietnamese population is not well known. Here we report the presence of five deletional mutations of Southeast Asia in the southern region of Vietnam. The – –SEA (NG_000006.1: g.26264_45564del19301) mutation is the most common type of deletion (87.35%), followed by the –α3.7 (rightward) (NG_000006.1: g.34164_37967del3804) deletion (9.64%), –α4.2 (leftward) (AF221717) deletion (2.41%) and – –THAI (NG_000006.1: g.10664_44164del33501) (0.6%) mutation in this region. The – –FIL (NG_000006.1: g.11684_43534del31581) mutation was not detected in this study. This result provided a view of the distribution of common α-globin gene mutations in Vietnam and could serve as a baseline for further investigations into these genetic defects.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.