Hb F-Catala or α₂^gy2l5(A12)Trp →Arg

D. Plaseska Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

J. B. Wilson Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

F. Kutlar Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

LI. Font Servei'Hematologia, Hospital Verge de la Cinta, Tortosa, Spain

H. Baiget Molecular Genetics Unit, Hospital Santa Creu i Sant Pau, 08025, Barcelona, Spain

T. H.J. Huisman Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

Abstract

Hb F-Catalonia, a ^Gγ chain variant with a Trp → Arg substitution at position γ 15(A12), was observed in two Spanish newborn babies from Northeastern Spain. Analyses were performed with different reversed phase high performance liquid chromatographic procedures that allowed the identification of the amino acid replacement in only a minute quantity of the isolated ^Gγ^X chain.

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Hb F-Catala or α₂^gy2l5(A12)Trp →Arg

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Hb F-Catala or α2gy2l5(A12)Trp →Arg

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Hb F-Catala or α₂^gy2l5(A12)Trp →Arg