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Hemoglobin
international journal for hemoglobin research
Volume 15, 1991 - Issue 4
72
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Original Article

Hb Westmead: An α2-Globin Gene Mutation Detected by Polymerase Chain Reaction and STU I Cleavage

, , , , &
Pages 291-295 | Received 02 Apr 1991, Accepted 10 May 1991, Published online: 07 Jul 2009
 

Abstract

Hb Westmead or α2122(H5)His→Glnβ2 is one of the most common hemoglobin variants in Guangxi, a province in Southern China. The α2-globin DNA sequence of a carrier for this variant was selectively amplified by the polymerase chain reaction and analyzed with the restriction enzyme Stu I. We found that this mutant globin was encoded at the α2 locus and that the CAG→CAG mutation at codon 122 created a new Stu I restriction site. It is easy to detect this mutation by these methods.

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