Erythrocyte Fructose 2,6-Bisphosphate Content in Congenital Hemolytic Anemias

D. Colomer Haematology Laboratory Department, Hospital Clinic i Provincial, University of Barcelona, 08036, Barcelona, Catalonia, Spain

A. Pujades Haematology Laboratory Department, Hospital Clinic i Provincial, University of Barcelona, 08036, Barcelona, Catalonia, Spain

E. Carballo Haematology Laboratory Department, Hospital Clinic i Provincial, University of Barcelona, 08036, Barcelona, Catalonia, Spain

J. L. Vives Corrons Haematology Laboratory Department, Hospital Clinic i Provincial, University of Barcelona, 08036, Barcelona, Catalonia, Spain

Abstract

We have investigated the levels of fructose 2,6-bisphosphate and its synthesizing enzyme 6-phosphofructo-2-kinase in red blood cells from different congenital anemias. Fructose 2,6-bisphosphate concentration and 6-phosphofructo-2-kinase activity are markedly influenced by the number of reticulocytes in all the cases studied with the exception of homozygous pyruvate kinase deficiency, where no correlation was observed with the percentage of reticulocytes.

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Erythrocyte Fructose 2,6-Bisphosphate Content in Congenital Hemolytic Anemias

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Erythrocyte Fructose 2,6-Bisphosphate Content in Congenital Hemolytic Anemias

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