Hb Graz or α₂β₂2(Na2)His→Leu; a new β Chain Variant Observed in four Families from Southern Austria

J. S. Liu Laboratory of Protein Chemistry Department of Biochemistry, Molecular Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

T. P. Molchanova Laboratory of Protein Chemistry Department of Biochemistry, Molecular Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

L. H. Gul Laboratory of Protein Chemistry Department of Biochemistry, Molecular Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

J. B. Wilson Laboratory of Protein Chemistry Department of Biochemistry, Molecular Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

P. Hopmeier Central Laboratory, Krankenanstalt udolfstiftung, 1030, Vienna, Austria

W. Schnedl Medical Department, Karl-Franzens-Niversität, 8036, Graz, Austria

E. Balaun Central Laboratory, Krankenanstalt udolfstiftung, 1030, Vienna, Austria

G. J. Krejs Medical Department, Karl-Franzens-Niversität, 8036, Graz, Austria

T. H. J. Huisman Laboratory of Protein Chemistry Department of Biochemistry, Molecular Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

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Abstract

Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A_1c. Structural analysis of isolated β chains and sequence analysis of amplified DNA identified a new variant, i.e. Hb Graz that has a His→Leu replacement at position 2 of the β chain, in four healthy, apparently unrelated, adults. The second variant was identical to Hb Sherwood Forest or α₂β₂104(G6)Arg→Thr; it is believed that this may be the second observation of this abnormal hemoglobin.

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Hb Graz or α₂β₂2(Na2)His→Leu; a new β Chain Variant Observed in four Families from Southern Austria

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Hb Graz or α2β22(Na2)His→Leu; a new β Chain Variant Observed in four Families from Southern Austria

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Hb Graz or α₂β₂2(Na2)His→Leu; a new β Chain Variant Observed in four Families from Southern Austria