Hb Bab-Saaooun or α₂β₂48(CD7)Leu→pro, A Mildly Unstable Variant Found in an Arabian Boy from Tunisia

T. P. Molchanova Laboratory of Protein Chemistry Department of Biochemistry and Molecular, Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

J. B. Wilson Laboratory of Protein Chemistry Department of Biochemistry and Molecular, Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

L-H. Gu Laboratory of Protein Chemistry Department of Biochemistry and Molecular, Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

F. Guemira Hopital d'Enfants, Place Bab-Saadoun, Tunis, Tunisie

S. Fattoum Hopital d'Enfants, Place Bab-Saadoun, Tunis, Tunisie

T. H. J. Huisman Laboratory of Protein Chemistry Department of Biochemistry and Molecular, Biology Medical College of Georgia, Augusta, GA, 30912-2100, USA

Abstract

Hb Bab-Saadoun which has a Leu→Pro substitution at position 48 of the β chain was detected in a young Arabian boy living in Tunisia. His parents did not have the variant which suggests that it occurred as a spontaneous mutation. The substitution is located in the interhelical CD segment; leucine at β48 is an invariable amino acid that may be important as part of a spacer sequence between the two helices and its replacement by proline may affect the stability of the hemoglobin molecule. Hb Bab-Saadoun is unstable in heat and isopropanol stability tests and its chain was best isolated by parachloromercuribenzoate precipitation. It appears unlikely that the presence of Hb Bab-Saadoun results in a hemolytic anemia.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Hb Bab-Saaooun or α₂β₂48(CD7)Leu→pro, A Mildly Unstable Variant Found in an Arabian Boy from Tunisia

Information for

Open access

Opportunities

Help and information

Hb Bab-Saaooun or α2β248(CD7)Leu→pro, A Mildly Unstable Variant Found in an Arabian Boy from Tunisia

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

Hb Bab-Saaooun or α₂β₂48(CD7)Leu→pro, A Mildly Unstable Variant Found in an Arabian Boy from Tunisia