HB Al-Ain Abu Dhabi [αl8(A16)GLY→ASP]: A New Hemoglobin Variant Discovered in an Emiratee Family

S. Abbes Department of Biology, Faculty of Sciences United Arab Emirates University, Al-Ain, United Arab Emirates

A. M'rad INSERM U 299, Hôpital de Bicětre, 94275, Le Kremlin-Bicçtre, France

P. A. Fitzgerald Departments of Hematology and Interna Medicine, Al-Tawam Hospital, Al-Ain, United Arab Emirates

P. Donner Departments of Hematology and Interna Medicine, Al-Tawam Hospital, Al-Ain, United Arab Emirates

Y. Blouquit INSERM U 91, Hôpital Henri Mondor, 94010, Créteil, France

J. Kister INSERM U 299, Hôpital de Bicětre, 94275, Le Kremlin-Bicçtre, France

F. Galacteros INSERM U 91, Hôpital Henri Mondor, 94010, Créteil, France

H. Wajcman INSERM U 299, Hôpital de Bicětre, 94275, Le Kremlin-Bicçtre, France

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Abstract

During a routine program of hemoglobin screening performed in the United Arab Emirates, we observed an electrophoretically fast-moving variant in a 9-month-old girl and in several members of her family. The structural determination, performed by reversed phase high performance liquid chromatography and amino acid sequencing, revealed a new variant that we named Hb A1-Ain Abu Dhabi [δ18(A16) Gly→Asp]. Its functional properties were normal.

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HB Al-Ain Abu Dhabi [αl8(A16)GLY→ASP]: A New Hemoglobin Variant Discovered in an Emiratee Family

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HB Al-Ain Abu Dhabi [αl8(A16)GLY→ASP]: A New Hemoglobin Variant Discovered in an Emiratee Family

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