Three Sickle Cell Anemia Patients Each with a Different α Chain Variant. Diagnostic Complications

L-H. Gu Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

J. B. Wilson Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

T. P. Molchanova Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

K. M. McKie Department of Pediatric-Hematology/Oncology, Medical College of Georgia, Augusta, GA, 30912-3730, USA

V. C. McKie Department of Pediatric-Hematology/Oncology, Medical College of Georgia, Augusta, GA, 30912-3730, USA

T. H. J. Huisman Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA

Abstract

We have studied three sickle cell anemia patients who also carried a heterozygosity for one of the following a chain abnormalities: Hb G-Philadelphia [α68(E17)Asn→Lys], Hb Montgomery [α 48 (CE6)Leu→Arg], and Hb Chicago [αl36(H19)Leu→Met]. Electrophoretic analyses alone may result in incomplete and incorrect information. Confirmation of the diagnosis of Hb SS or Hb SC disease by one of the fast high performance liquid chromatographic procedures is recommended.

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Three Sickle Cell Anemia Patients Each with a Different α Chain Variant. Diagnostic Complications

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Three Sickle Cell Anemia Patients Each with a Different α Chain Variant. Diagnostic Complications

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