Two New Rat α-Globin Sequences as Identified by the Conserved Region PCR

V. M. S. Lam Department of Biochemistry, University of Hong Kong, Hong Kong

Y. L. Gu Department of Biochemistry, Shanghai Medical University, Shanghai, People's Republic of China

D. M. Y. Au Department of Biochemistry, University of Hong Kong, Hong Kong

W. M. Wong Department of Biochemistry, University of Hong Kong, Hong Kong

C. W. Ma Department of Biochemistry, University of Hong Kong, Hong Kong

L. Y. L. Cheng Department of Biochemistry, University of Hong Kong, Hong Kong

Abstract

Based on the notion that regions of structural genes which encode critical domains of the corresponding proteins are highly conserved among closely related species, oligonucleotide primers were designed and used to amplify the α-globin sequence(s) of the Sprague-Dawley (SD) rat. Data of these amplified sequence constructs showed that two new rat a-globin specific sequences have been identified. Southern hybridization confirmed the presence of these sequences in the rat genome.

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Two New Rat α-Globin Sequences as Identified by the Conserved Region PCR

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Two New Rat α-Globin Sequences as Identified by the Conserved Region PCR

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