Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 17, 1993 - Issue 3
16
Views
8
CrossRef citations to date
0
Altmetric
Original Article

HB Karlskoga or α2β221(B3) ASP→HIS: A new Slow-Moving Variant Found in Sweden

Pages 201-208 | Received 13 Nov 1992, Accepted 11 Feb 1993, Published online: 07 Jul 2009
 

Abstract

An abnormal variant comprising approximately 39% of total hemoglobin was found in a 48-year-old Swedish woman. The variant was eluted from ion exchange high performance liquid chromatography (HPLC) used for routine quantification of Hb A1c at a position similar to Hb S. Amplification of β-globin exons and nucleotide sequencing revealed heterozygosity for a GAT→CAT mutation in codon 21, corresponding to the amino acid substitution Asp→His at position 21. This mutation was confirmed by amino acid composition and peptide sequence determinations. Substitutions in this position are not likely to affect the function of the hemoglobin molecule and the hemoglobin variant, for which the name Hb Karlskoga is proposed, was not associated with any overt hematological abnormalities.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.