A New β Chain Variant, Hb Tyne [β5(A2)Pro->ser]

J. V. Langdown Department of Haematology Addenbrookes, National Health Service Trust Cambridge, CB2 2QQ, England

D. Williamson Department of Haematology, University of Cambridge Medical Research Council Centre Cambridge, CB2 2QH, England

C. H. Beresford Department of Clinical Biochemistry, The Royal Victoria Infirmary, Newcastle, Upon Tyne, NE1 4LP, England

I. Gibb Department of Clinical Biochemistry, The Royal Victoria Infirmary, Newcastle, Upon Tyne, NE1 4LP, England

R. Taylor Department of Clinical Biochemistry, The Royal Victoria Infirmary, Newcastle, Upon Tyne, NE1 4LP, England

R. Deacon-Smith Department of Haematology Poole, Hospital National Health Service Trust Poole, Dorset, BH15 2JB, England

Abstract

We have identified a new β chain hemoglobin (Hb) variant in a 66-year-old diabetic male after an inappropriately low level of glycosylated Hb was detected by enzyme immunoassay, and confirmatory ion exchange high performance liquid chromatography (HPLC) revealed the presence of an abnormal Hb. We have subsequently identified the same Hb mutation in an apparently unrelated diabetic male, again following its detection by HPLC.

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A New β Chain Variant, Hb Tyne [β5(A2)Pro->ser]

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A New β Chain Variant, Hb Tyne [β5(A2)Pro->ser]

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