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Abstract
Hb Ramona was accidentally detected in a pregnant female of part Spanish descent who was tested during a prenatal physical examination program for the possible presence of a hemoglobin (Hb) variant. Her hematological values were normal: Hb 12.3 g/dl; PCV 0.418 l/l; RBC 4.34 × 1012/l; MCV 96.3 fl; MCH 28.3 pg; MCHC 29.4 g/dl. The variant was detected by isoelectrofocusing (IEF) (1); its mobility was slightly faster than that of Hb A. It could not be separated from Hb A by cation exchange high performance liquid chromatography (HPLC) (2,3), nor did a variant α or β chain separate from the corresponding normal chains by reversed phase HPLC (4,5).