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Hemoglobin
international journal for hemoglobin research
Volume 18, 1994 - Issue 1
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Original Article

Hb CAPA OR α2 94(G1)ASP→GLYβ2, A Mildly Unstable Variant with an A↠G (Gac↠Ggc) Mutation in Cown 94 of the α1-Globin Gene

G. Dinçol Hematology Clinic, University o f Istanbul Istanbul, Turkey
,
K. Dinçol Hematology Clinic, University o f Istanbul Istanbul, Turkey
,
S. Erdem Hematology Clinic, University o f Istanbul Istanbul, Turkey
,
D. D. Pobedimskaya Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
,
T. P. Molchanova Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
,
Z. Ye Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
,
B. B. Webber Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
,
J. B. Wilson Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
&
T. H. J. Huisman Laboratory of Protein Chemistry Department of Biochemistry and Molecular Biology, Medical College o f Georgia, Augusta, GA, 30912-2100, USA
 show all
Pages 57-60 | Received 12 Aug 1993, Accepted 09 Nov 1993, Published online: 07 Jul 2009
 
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Abstract

A 28-year-old female from the city of Kars in Turkey was treated for a chronic iron deficiency anemia with oral iron. During the clinical evaluation a slowly moving hemoglobin (Hb) variant was detected which migrated about like Hb F in alkaline electrophoresis and like Hb S in agar electrophoresis at pH 6.2. The variant appeared mildly unstable in a heat denaturation test (60°C) but the isopropanol stability test was questionably positive (for methodology, see Ref. 1).

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Related Research Data

Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.
Source: Elsevier BV
Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok).
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Hemoglobin Sunshine Seth - α2(94 (G1) Asp→His)β2
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Construction of Human Gene Libraries from Small Amounts cf Peripheral Blood: Analysis of β-Like Globin Genes
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High Performance Liquid Cbromatographic Separation of Globin Chains on a Large-Pore C4 Column
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Separation of tryptic peptides of normal and abnormal a, β, γ, and δ hemoglobin chains by high-performance liquid chromatography
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High-performance liquid chromatographic separation of human haemoglobins. Simultaneous quantitation of foetal and glycated haemoglobins.
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Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity
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