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Hemoglobin
international journal for hemoglobin research
Volume 18, 1994 - Issue 1
26
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Original Article

Hb D-Iran [β22(B4)6Lu↠6Ln] in Southern Italy

, , , , &
Pages 65-69 | Received 17 Jun 1993, Accepted 04 Nov 1993, Published online: 07 Jul 2009
 

Abstract

During the past 10 years we have screened by electrophoresis 126,000 subjects from Northern Calabria for hemoglobinopathies, and identified 36 subjects belonging to 24 unrelated families as carriers of a hemoglobin (Hb) with a mobility slower than Hb A. Structural analysis has identified it as Hb D-Iran [β22(B4)Glu→ Gln], which was first described in 1973 (1). However, as early as in 1959 one of us discovered an abnormal Hb in Italy, which was electrophoretically identified as Hb D but was not specifically characterized (2).

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