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Hemoglobin
international journal for hemoglobin research
Volume 18, 1994 - Issue 3
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Original Article

Quantitative transformation of hemoglobin into stable tetramers

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Pages 185-192 | Received 27 Aug 1993, Accepted 15 Dec 1993, Published online: 07 Jul 2009
 

Abstract

A method is described for the preparation of human or bovine hemoglobin with a covalent bridge, formed by bispyridoxal-tetraphosphate, between the β chains. The yield is 95% of the total hemoglobin. The location of the two molecules of bispyridoxal-tetraphosphate in the tetramer has been established. The functional properties of the cross-linked hemoglobin, its stability, and particularly, the simplicity of the method for its preparation, make it a promising candidate for an acellular blood substitute.

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