Two Fetal Hemoglobin Variants Affecting the Same Residue: HB F-Emirates [^Gγ59(E3)LYS→GLU] and HB F-Sacromonte [^Gγ59(E3)LYS→GLN]

S. Abbes Département de Biochimie, Faculté de Medicine de Tunis, Tunisie

P. A. Fitzgerald Tawam Hospital, Al AinUnited Arab Emirates

E. Varady Tawam Hospital, Al AinUnited Arab Emirates

R. Girot Laboratoire d'Hématologie, Hôpital Tenon, Paris, France

P. Pic Laboratoire d'Hématologie, Hôpital Tenon, Paris, France

Y. Blouquit INSERM U91, Hôpital Henri Mondor, Créteil, France

R. Ducrocq Biochimie Génétique, Hôpital Robert Debré, Paris, France

F. Drupt Laboratoire d'Hématologie, Hôpital Foch, Suresnes, France

H. Wajcman INSERM U91, Hôpital Henri Mondor, Créteil, France

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Abstract

Two fast-moving fetal hemoglobin variants were discovered in hematologically normal newborn babies; the first originated in the United Arab Emirates and the second in France. The structural study, carried out by miniaturized techniques of protein chemistry, showed that these two mutations affected the same residue of the ^Gγ chain, the lysine at position 59(E3) was replaced by glutamic acid in Hb F-Emirates, and by glutamine in Hb F-Sacromonte.

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Two Fetal Hemoglobin Variants Affecting the Same Residue: HB F-Emirates [^Gγ59(E3)LYS→GLU] and HB F-Sacromonte [^Gγ59(E3)LYS→GLN]

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Two Fetal Hemoglobin Variants Affecting the Same Residue: HB F-Emirates [Gγ59(E3)LYS→GLU] and HB F-Sacromonte [Gγ59(E3)LYS→GLN]

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Two Fetal Hemoglobin Variants Affecting the Same Residue: HB F-Emirates [^Gγ59(E3)LYS→GLU] and HB F-Sacromonte [^Gγ59(E3)LYS→GLN]