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Abstract
Approximately 700 hemoglobin variants have been reported, causing a variety of clinical manifestations, with the majority being clinically silent. We report a new hemoglobin variant, Hb Cook, that was found in combination with Hb E in a child of Thai origin. DNA sequencing of the β-globin gene showed that the mutation is AAA → ACA in codon 132, corresponding to β132 (MO)Lys → Thr.