HB Silver Springs [β131(H9)GLNHIS], A New Hemoglobin Variant Found in Six African-Americans

J. D. Hoyer Department of Laboratory Medicine, Pathology Mayo Clinic, Rochester, MN, 55905, USA

M. J. Wick Department of Laboratory Medicine, Pathology Mayo Clinic, Rochester, MN, 55905, USA

S. N. Thibodeau Department of Laboratory Medicine, Pathology Mayo Clinic, Rochester, MN, 55905, USA

K. S. Kechteiger Department of Laboratory Medicine, Pathology Mayo Clinic, Rochester, MN, 55905, USA

J. D. Cook Quest Diagnostic, Inc., Baltimore, MD, 21227, USA

V. F. Fairbanks Department of Laboratory Medicine, Pathology Mayo Clinic, Rochester, MN, 55905, USA

Abstract

We report a new hemoglobin variant which we have named Hb Silver Springs. This variant results from a substitution CAGĆC (GlnHis) at codon 131 of the β chain. It was detected only by cation exchange high performance liquid chromatography. This is the fifth reported substitution at codon 131. This variant does not appear to have any clinical or hematologic manifestations.

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HB Silver Springs [β131(H9)GLNHIS], A New Hemoglobin Variant Found in Six African-Americans

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HB Silver Springs [β131(H9)GLNHIS], A New Hemoglobin Variant Found in Six African-Americans

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