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Hemoglobin
international journal for hemoglobin research
Volume 22, 1998 - Issue 3
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Original Article

Pharmacologic Hemoglobin Reversal: The Importance of Lipid Intermediaries and the Proposed Involvement of the Camp and Phosphatidylinositol Second Messenger Systems

, , , , , , & show all
Pages 245-261 | Received 25 Jul 1997, Accepted 20 Feb 1998, Published online: 05 Aug 2009
 

Abstract

Humoral and microenvironmental influences have played a major role in recent research into reversing the Hb F to Hb A switch. Early research in this area focused on hormonal influences and showed both thyroid hormone and prolactin could induce small but statistically significant reversals in hemoglobin phenotype. Recent research has focused on the effect of certain lipids in this process. The current study shows a synergy between thyroid hormone and prolactin in inducing a significant switch in adult rat hemoglobin patterns toward the neonatal pattern. Further, it is hypothesized that this synergy is due to the horjmones' effect on lipid intermediaries whose effect in turn are proposed to be mediated by the cAMP and phosphatidylinositol second messenger systems.

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