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Hemoglobin
international journal for hemoglobin research
Volume 23, 1999 - Issue 3
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Original Article

Hb Harrow [β118(GH1)Phe→Cys]: A New Neutral Hemoglobin Variant

, , , , , , & show all
Pages 273-279 | Received 17 Feb 1999, Accepted 07 Apr 1999, Published online: 07 Jul 2009
 

Abstract

We report here on a new hemoglobin (Hb) variant found in a newborn baby boy of Indian Gujerati origin, living in the Harrow area of London, England. This variant was observed during a systematic program of neonatal screening for the main hemoglobinopathies performed at the Central Middlesex Hospital in the North Thames (West) Region of London. In this program, the samples are collected from a heelprick onto filter paper when the child is 7-10 days old. A dried blood spot of 0.3 cm diameter is obtained from which Hb is eluted by a 5 mM KCN solution to be analyzed by isoelectrofocusing (IEF).

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