Abstract
Hb Köln [β98(FG5)Val→Met] is the most common unstable hemoglobin (Hb) variant, causing hemolytic anemia of varying clinical severities (1). Hb Köln was first described in 1962, and the structural abnormality of the variant was determined in 1966 (2). The variant has increased oxygen affinity, and shows a left-shifted oxygen dissociation curve (3,4). The first case of Hb Köln in Koreans is described in this paper.