The First Case of Hb Köln [β98(FG5)Val→Met] in Korea

Y. H. Chang Department of Clinical Pathology, Seoul National University College of Medicine Seoul, 110-744, Korea

M. Hur Department of Clinical Pathology, Seoul National University College of Medicine Seoul, 110-744, Korea

D. S. Lee Department of Clinical Pathology, Seoul National University College of Medicine Seoul, 110-744, Korea

S. S. Park Department of Clinical Pathology, Seoul National University College of Medicine Seoul, 110-744, Korea

B. K. Kim Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea

S. Park Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea

Y. Ohba Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, 755-8505, Japan

Y. Hattori Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, 755-8505, Japan

H. I. Cho Department of Clinical Pathology, Seoul National University College of Medicine Seoul, 110-744, KoreaCorrespondence[email protected]

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Abstract

Hb Köln [β98(FG5)Val→Met] is the most common unstable hemoglobin (Hb) variant, causing hemolytic anemia of varying clinical severities (1). Hb Köln was first described in 1962, and the structural abnormality of the variant was determined in 1966 (2). The variant has increased oxygen affinity, and shows a left-shifted oxygen dissociation curve (3,4). The first case of Hb Köln in Koreans is described in this paper.

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The First Case of Hb Köln [β98(FG5)Val→Met] in Korea

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The First Case of Hb Köln [β98(FG5)Val→Met] in Korea

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