Design of a 24-hour controlled porosity osmotic pump system containing PVP: formulation variables

Abstract

Purpose: The purpose of this study was to design a 24-hour controlled porosity osmotic pump system that utilizes polyvinyl pyrrolidone (PVP) as an osmotic-suspending/release retarding agent of drugs. Methods: Osmotic tablet cores containing various ratios of ketoprofen and PVP were prepared by wet granulation and initially spray coated with similar solution of cellulose acetate. A formulation containing ketoprofen and PVP at a ratio of 1:7 was selected for further studies. Results: The final formulation containing PVP K-30 in the tablet core augmented the release of ketoprofen (poorly water-soluble) up to 90 % over 24 hours much higher than either PVP K-25 or PVP K-90 and retarded the release of pseudoephedrine HCl (highly water-soluble) up to 18 hours. Conclusion: This study proposed the dual use of PVP in osmotic pump systems containing solids to modulate the release of either poorly or highly water-soluble drug.

Keywords:

• Controlled porosity osmotic pump design
• formulation variables
• ketoprofen
• polyvinyl pyrrolidone
• pseudoephedrine HCl

Acknowledgment

The sponsorship received from the Jigawa State Government of Nigeria for the M.Sc study was appreciated.

Declaration of interest: The authors report no conflicts of interest.