Incorporation of paclitaxel solid dispersions with poloxamer188 or polyethylene glycol to tune drug release from poly(ϵ-caprolactone) films

Abstract

Here we report the application of solid dispersion (SD) technique to improve paclitaxel (PTX) release from poly(ϵ-caprolactone) (PCL)-based film. Paclitaxel solid dispersions (SDs) with either poloxamer188 (PXM) or polyethylene glycol (PEG) were successfully prepared by a melting method and then incorporated into PCL films, which were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and In vitro drug release/dissolution studies. It was found that PTX was faster released from the SDs than the corresponding physical mixtures (PMs) or PTX alone. For the PCL films with almost the same PTX loading, drug release from films containing SDs was remarkably faster than that from the film directly incorporated with PTX particles, and the films containing SDs with PXM exhibited a faster drug release than those with PEG. An increase In the content of PXM had no significant influence on PTX release from the films containing SDs. Incorporation of a higher content of SDs led to slower drug release from PCL films, indicating that PTX loading had a dominating effect on drug release. Through this study, we demonstrated the feasibility of the application of SD technique on the improvement of PTX release from PCL films and offered some beneficial information on modulating drug release behavior by changing the compositions and contents of the SDs-loaded PCL films.

Keywords::

• Solid dispersion
• paclitaxel (PTX)
• poloxamer188
• polyethylene glycol (PEG)
• poly(ϵ-caprolactone) (PCL)
• drug release

Acknowledgements

We are grateful to Instrumental Analysis Center of Shanghai Jiao Tong University for their technical support.

Declaration of interest

This work is supported by National Natural Science Foundation of China (NSFC) (Grant No. 81171439, 81173015 and 30901882), Key Program of Shanghai Science and Technology Committee (Grant No. 10441902000) and Medicine-Engineering joint foundation at Shanghai Jiao Tong University (Grant No. YG2010MS63).