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Research Article

Influence of pressurized carbon dioxide on ketoprofen-incorporated hot-melt extruded low molecular weight hydroxypropylcellulose

Eman A. AshourDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA,

Vijay KulkarniDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA,

Bjad AlmutairyDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA,

Jun-Bom ParkDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA,

Sejal P. ShahDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA,

Soumyajit MajumdarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA, ;Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS, USA

Zhuoyang LianAshland Specialty Ingredients, Global Pharma R&D, Wilmington, DE, USA,

Elanor PintoAshland Specialty Ingredients, Global Pharma R&D, Wilmington, DE, USA,

Vivian BiAshland Specialty Ingredients, Global Pharma R&D, Wilmington, DE, USA,

Thomas DurigAshland Specialty Ingredients, Global Pharma R&D, Wilmington, DE, USA,

Scott T. MartinThermo Fisher Scientific, Tewksbury, MA, USA, and

Michael A. RepkaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA, ;Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS, USACorrespondence[email protected]

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Abstract

Objectives: The aim of the current research project was to investigate the effect of pressurized carbon dioxide (P-CO₂) on the physico-mechanical properties of ketoprofen (KTP)-incorporated hydroxypropylcellulose (HPC) (Klucel™ ELF, EF, and LF) produced using hot-melt extrusion (HME) techniques and to assess the plasticization effect of P-CO₂ on the various polymers tested.

Methods: The physico-mechanical properties of extrudates with and without injection of P-CO₂ were examined and compared with extrudates with the addition of 5% liquid plasticizer of propylene glycol (PG). The extrudates were milled and compressed into tablets. Tablet characteristics of the extrudates with and without injection of P-CO₂ were evaluated.

Results and conclusion: P-CO₂ acted as a plasticizer for tested polymers, which allowed for the reduction in extrusion processing temperature. The microscopic morphology of the extrudates was changed to a foam-like structure due to the expansion of the CO₂ at the extrusion die. The foamy extrudates demonstrated enhanced KTP release compared with the extrudates processed without P-CO₂ due to the increase of porosity and surface area of those extrudates. Furthermore, the hardness of the tablets prepared by foamy extrudates was increased and the percent friability was decreased. Thus, the good binding properties and compressibility of the extrudates were positively influenced by utilizing P-CO₂ processing.

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Declaration of interest

This project was partially supported by Grant no. P20GM104932 from the National Institute of General Medical Science (NIGMS), a component of NIH. The authors report that they have no conflict of interest.

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Influence of pressurized carbon dioxide on ketoprofen-incorporated hot-melt extruded low molecular weight hydroxypropylcellulose

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Influence of pressurized carbon dioxide on ketoprofen-incorporated hot-melt extruded low molecular weight hydroxypropylcellulose

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