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Abstract
Four commercially available tablet preparations containing 50 mg, and on the other hand, 100 mg nitrofurantoin as well as a test preparation containing 4–5 mg nitrofurantoin was studied in vitro. The tested products meet TISP. XIX specifiactions for drug content and weight. Statistically siginificant differences were recorded between the different preparations with regard to their in vitro availability. Two of the commercial preparations and the test preparation did not meet the USE dissolution requirements for nitrofurantoin tablets.