Utility of Gas Permeation as a Means of Protection for Oxygen Sensitive Systems

Abstract

In this study, the utility of a gas permeator for decreasing the dissolved oxygen content of aqueous vehicles was determined at ambiant temperatures. Since decarbonation of water also takes place, the pH of the resulting decarbonated, deoxygenated water was very nearly neutral. Oxidative decomposition of two model compounds, phenylephrine and hydroquinone, was determined for several methods of protection such as nitrogen flushing and the addition of a chelating, agent versus depletion of dissolved oxygen by permeation. It was found that permeated vehicles compared favorably to the other methods in relative protection of oxygen sensitive moieties.