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Abstract
The sulfite induced anaerobic degradation of epinephrine in lidocaine hydrochloride injection, U.S.P. was studied, at pH 4.0 and 4.4. The epinephrine concentration was 0.001 per cent. The activation energy parameters were evaluated from arrhenius type plots. DLH was found to be 23.6 and 23.9 kcal mole−1 for pH 4.0 and 4.4 respectively and compared favourably with literature value. Based on these results, shelf life was predicted and changes in U.S.P. monograph are suggested.
The anaerobic degradation of epinephrine in aqueous solution over the 3.63–5.00 pH range was reported earlier (1) as a preliminary to stability studies on products containing epinephrine. The degradation of epinephrine was induced by sodium metabisulfite.
The purpose of this investigation was to study the sulfite induced anaerobic degradation of epinephrine in Lidocsine Hydrochloride Injection, U.S.P.