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Abstract
The vapor pressure osmometer was used to calculate the sodium chloride equivalents of several compounds. These values were compared with published values and in some cases, considerable variation was seen. The osmolality was determined for iso-osmotic drug solutions mixed in different ratios with iso-osmotic saline or sorbitol. The drugs investigated included atropine sulfate, te-tracycline hydrochloride, homatropine hydrobromide, pilocarpine nitrate, amphetamine sulfate and bromodiphenhydramine hydrochloride. The results of these studies showed that colligative properties of multicomponent aqueous solutions are often non-additive in manner. The changing osmolality suggests that ion-ion or ion-molecule forces are occurring and when osmolality increases, so does the number of particles in solution.