The Application of Non-Isothermal Accelerated Kinetic Study in Pharmaceutical Product Development

Abstract

A non-isothermal kinetic study allows the determination of the important kinetic parameters in a single experiment and thus is useful for the quick assessment of stability characteristics of the pharmaceutical prototypes during the development stage. The applicability and limitations of two non-isothermal accelerated kinetic methods in the pharmaceutical product development are discussed. Both methods are simple and no sophisticated calculation is necessary. These methods, however, fail to provide a unique reaction order for the pharmaceutically acceptable systems. The method is applicable only to those systems which obey the Arrhenius relationship.