Abstract
Soy polysaccharide was evaluated as a disintegrating agent in tablets made by wet granulation utilizing both lactose and dicalcium phosphate dihydrate as fillers, gelatin as a granulating agent and hydrochlorothiazide as a model drug. It was found to be more effective than starch but less effective than cross-linked carboxymethylcellulose (Ac-Di-SolR) at equivalent concentrations. Soy polysaccharide appears to reduce the friability of tablets as concentration increases. Tablets containing either Soy polysaccharide or cross-linked carboxymethylcellulose showed no changes in dissolution profiles after storage under ambient conditions for six months.