Crystallization of Halidixic Acid in Presence of Different Carriers

Abstract

The wettability of nalidixic acid powder was improved by using different tensioactive agents especially with Hyrj 59, Brij 35 and Tween 40. There was an optimal concentration for each tenside which Produced a maximal wettability.

The unique method of crystallization of nalidixic acid, in presence of different carriers, showed great enhancement in its dissolution rate. Maximum enhancing effects were shown with 1% w/v Myri 59 or hexamine and 5% w/v each of FVP and urea. The drug yield, in general, was high in all systems and the flow properties of the crystallized drug powder were also improved.