Carbopol-gelatin coacervation and drug microencapsulation

Abstract

Carbopol-gelatin coacervates were recovered as water-insoluble powder which when suspended in water gave a highly disperse system.

Glycerol as a protective against coacervate deformation, formaldhyde as a denaturant and some monohydric aliphatic alcohols as flocculating agents were variables studied. The hypothesis that solid particles may be protectively encapsulated by coacervation led to the investigation of the encapsulation of sulfadiazine at four coat-core ratios. The surface-adhering drug as well as the percentage of drug in the microcapsule increased on raising the core ratio. The size distribution was determined by use of standard sieves and the influence of four coat/core ratios was noted. Availability studies show that sulphadiazine was readily accessable to the leaching effect of the artifical intestinal fluids.