Dissolution Rates of Prednisolone Triturations Using Porous and Non-Porous Silicas. I. Pilot Oral Absorption Study in Dogs

Abstract

Prednisolonei:Silica triturations were prepared with 5 grades of silicas by ball-milling and solvent deposition. Drug:Silica ratios ranged from 1:0.11 to 1:19. Dissolution rates in simulated intestinal juice were greatest for the l:0.11 triturations prepared by solvent-deposition. Oral absorption efficiency of prednisolone in dogs was similar whether administered as porous or non-porous silica triturations.