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Abstract
The effect of re-compression on the properties of tablets prepared by moist granulation using various binding agents was examined. The results show that re-working by dry granulation and re-compression (i.e. a slugging process) caused a reduction in tablet strength, which was related to the initial compaction pressure. This loss of compressibility was attributed to work hardening of granules during the compaction process. However, when compacts were milled, re-wetted and then re-compressed, the tablets produced were of similar strength to those obtained on initial compaction. Re-wetting reversed the effect of work hardening by reactivating the binder to produce granules more porous than those obtained by dry granulation.
This paper is based on a presentation made to the 31st National meeting of the Academy of Pharmaceutical Sciences, American Pharmaceutical Association, held at Orlando, Florida, U.S.A. on November 15-19th, 1981.