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Abstract
Substituted phenyl boronate esters of chloramphenicol have significant antimicrobial potency against common pathogens. The isosteric 1,3-dioxanes in which the boron atom has been replaced by a methine group are inactive under the conditions of test, The coronate esters are regarded as having the same conformation as the parent antibiotic; Photochemical degradation of these esters by simulated sunlight proceeds much faster than it does with chloramphenicol.