Mechanism of Transdermal Controlled Nitroglycerin Administration (II) Assessment of Rate-Controlling Steps

Abstract

The mechanisms and the rates of skin permeation of nitroglycerin delivered by four transdermal therapeutic systems were investigated using hairless mouse skin mounted on a newly-developed and well-calibrated Keshary-Chien skin permeation system. Experiments were carried out to identify and characterize the rate-controlling roles of stratum corneum, controlled-release drug delivery system and dermal solution sink in the transdermal controlled administration of nitroglycerin.