In Vitro and Invivo Evaluation of Some Fast Release Dosage Forms of Hydrochlorothiazide

Abstract

The utilization of ternary sugar solid dispersion and solvent deposition systems for increasing the dissolution rate of hydrochlorothiazide (hot) were investigated. The dispersion systems were prepared by the fusion method using various combinations of mannitol and sorbitol, and urea and polyethylene glycol 4000 (peg 4000) were used for comparison. An 1:2 mixture of sorbitol-mannitol was found to be an excellent carrier. The dissolution rate of this sample was closely comparable to that of hot-peg 4000 solid dispersions. Drug-urea eutectic mixtures were inferior to both the sugar and polymer dispersions. Solvent deposition systems of hot with microfine cellulose and potato starch gave higher dissolution rates at the initial sampling times. It is proposed that solid dispersion systems of this drug may prove to be valuable. Tablets fabricated from fast-release hot granules showed better in vivo results than a marketed tablet. A linear relationship was observed between in vitro-in vivo data of some of the products.