Effect of Different Grades of Polyvinylpyrrolidone on Dissolution Rate of Chlorpropamide and its Absorption Through Rat Stomach

Abstract

Coprecipitates of chlorpropamide and PVP 10000, 44000 and 700000 were prepared. Dissolution rate studies have shown that coprecipitate of Chlorpropamide and PVP 44000 (1:3.33) is by far the best combination. The same findings were also observed when all the three different coprecipitates were subjected to drug absorption studies through rat stomach. This increase in dissolution rate could be due to complex formation between the drug and the PVP irrespective of molecular weight, this was confirmed by T.L.C. and IR studies. It was also observed that the effect of PVP on increase in dissolution of insoluble drug reaches up to a certain molecular weight of PVP and decreases with further increase in molecular weight.