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Research Article

High-Performance Liquid Chromatographic Determination of Ibuprofen in Bulk Drug and Tablets

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Pages 1123-1131 | Published online: 20 Oct 2008
 

Abstract

A simple and rapid HPLC procedure is described for the assay of ibuprofen in bulk drug and tablets and for dosage uniformity testing. HPLC was carried out on a stainless steel octadecylsilane (5 urn) column (150 × 4.6 mm) using 25% 0.25M glacial acetic acid in acetonitrile as the mobile phase, with UV detection at 254 nm. Results obtained with this procedure compared favorably with those obtained using the USP procedures.

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