Solubilization of Paracetamol Using Non-Ionic Surfactants and Co-Solubilizers

Abstract

The influence of certain aqueous non-ionic surfactants, cosolvents and cosolvent - surfactant blends on the enhanced solubility of paracetamol were studied. Dielectric constants of these solvent systems with and without paracetamol were determined. In several instances, paracetamol was increased in solubility by 5-7 fold, depending on the system used. Dielectric constants were affected to varying degrees by these systems.

The cosolvents, propylene glycol and glycerin apparently suppress micelle formation.