Abstract
One hundred fifty sheep received various types of Rate-Control vaginal pessaries for a period of up to 19 days at various geographic locations. As predicted from the in vitro studies, a constant (Q – t) absorption profile was also observed in in vivo. The effect of the loading dose of flurogestone acetate on the in vitro and in vivo absorption profiles were examined and minimum effective loading dose was determined. An excellent the prediction of the long-term (19-day) in vivo absorption profiles from a short-term (3-day) in vitro absorption study.