Simple Evaluation Method of Intrinsic Diffusivity for Membrane-Moderated Controlled Release

Kakuji Tojo Controlled Drug-Delivery Research Center Rutgers University, College of Pharmacy Piscataway, New Jersey, 08854

Ying Sun Controlled Drug-Delivery Research Center Rutgers University, College of Pharmacy Piscataway, New Jersey, 08854

Musa Ghannam Controlled Drug-Delivery Research Center Rutgers University, College of Pharmacy Piscataway, New Jersey, 08854

Yie W. Chien Controlled Drug-Delivery Research Center Rutgers University, College of Pharmacy Piscataway, New Jersey, 08854

Abstract

The effect of diffusion boundary layers in an in vitro membrane permeation system on the membrane diffusivity of drugs was investigated based on the three-layer model. A simple method for evaluating the intrinsic diffusivity through the membrane was developed and the intrinsic diffusivity of progesterone and testosterone through a silicone membrane were determined using this approach.

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Simple Evaluation Method of Intrinsic Diffusivity for Membrane-Moderated Controlled Release

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Simple Evaluation Method of Intrinsic Diffusivity for Membrane-Moderated Controlled Release

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