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Abstract
The physico-pharmaceutical properties of different batches of two brands of sodium starch glycolate have been investigated as disintegrant in direct compression. Differences in disintegration efficiency were found to be related to the purity of the products. The differences, however, were too small to have practical significance. The currently available low-sodium chloride content sodium starch glycolates may consequently be considered as being pharmaceutically equivalent, when used as disintegrant in tablet formulations.