A Note on the Solubility of Progesterone in Aqueous Polyethylene Glycol 400

M. D. Fulford Department of Pharmaceutics, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois, 60612

J. E. Slonek Department of Pharmaceutics, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois, 60612

M. J. Groves Department of Pharmaceutics, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois, 60612

Abstract

The solubility curve of progesterone in aqueous polyethylene glycol (PEG) 400 at ambient room temperature (∼25°C) is bimodal, a break occurring at approximately 60% w/w PEG.

It is speculated that the presence of unbound water in the PEG 400/water system depresses the solubility of progesterone in PEG 400 disproportionately.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A Note on the Solubility of Progesterone in Aqueous Polyethylene Glycol 400

Information for

Open access

Opportunities

Help and information

A Note on the Solubility of Progesterone in Aqueous Polyethylene Glycol 400

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature