A New Approach for Enhancing the Dissolution Rate of Phenacetin

Abstract

Numerous attempts are conducted so as to develop a rapid dissolution rate for those poorly water-soluble drugs. A new approach for enhancing the intrinsic dissolution rate of phenacetin is ascribed. This technique is based on the concept of the recrystallization of phencetin from different surfactants concentrations. The observed enhancing effect in the dissolution rate of phenacetin, using this technique, may be cue to wetting and/or deaggregation effect. The dissolution rate study was investigated in 0.1 N HC1 at 37°C and 50 r.p.m. The experimental study showed that the dissolution rate, during the first few minutes, is markedly affected by this technique. The relative area under the curve from 0 to 30 minutes (R.A.U.C.) was used as a parameter to 0–30 compare the different dissolution rates of the drug after being recrystallized from 1% w/v of each surfactant solution. The extent, in the dissolution rate enhancing effect, was found to range from 2.66 to 3.25 times of that of the control. This technique is valuable as a preformulation phase of phenacetin in solid dosage forms.