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Abstract
Tablet properties of 3 different commercial brands of furosemide tablets from different marufacturers have been investigated. Their dissolution characteristics were determined by using USP rotating basket method and two different pH degrees as the test medium. At pH 4.6 a large variation in the dissolution rate of these brands was observed. The release rate differed from one lot to another.
The effect of methods of tablet processing on furosemide release was also studied. A poor dissolution profile was observed with the tablet prepared by direct compression. The best result was obtained with the wet-granulation and the further study is extended on this process.