Abstract
The effect of wet-mixing time and the volume of granulating solution on furosemide tablet quality and in vitro dissolution rate were studied. The wet-mixing time has shown an effect on the in vitro dissolution of furosemide tablet formulation. Small variations in wet-mixing time can be important and effective on the tablet dissolution. A decrease in the dissolution rate was observed when the time of wet-mixing increased.
Changes in the volume of granulating solution, when the amount of gelatin was constant, did not alter the tablet dissolution.
Moreover, the effect of batch variation on tablet formulation was also investigated. There was no significant differences in the dissolution of the different batch of furosemide bulk powder.