Abstract
The in-vitro release of diltiazem from pharmaceutical equivalents of sustained release tablets, commercially available in Italy, was studied.
The in-vitro release profiles were determined by means of different methods and apparatus. Paddle, basket, Poole, Diffutest and Stricker methods were compared.
The absorption rates in artificial gastric and enteric juices by means of lipid barriers were calculated.
Some preparations showed a diffusion mechanism, some a first-order release.
The differences among the dissolution profiles of the formulations were enhanced with the Strieker method.