The Effect of Hydrodynamic Coditions and Delivery Orfice Size on the Rate of Drug Relase Fromthe Elemetnary Osmotic Pump System (EOP)

Abstract

The result obtained in this study indicate that the release of potassium choloride from EOP system is controlled by the agitation intensity and the nature of fluid flow. The size of delivery orifice has no effect on the delivery rate at low agitation speeds, but at higher agitation and under turbulent fluid flow, the orifice size has significant effect. In the absence of delivery orifice in EOP system, the release of potassium chloride took place through the pores formed in the membrane with an initial lag period of about two hours.

Key Words::

• Elementary osmotic pump
• Hyorodynamic conditions
• Fluid flow pattern
• Delivery orifice size
• Potassium chloride
• delivery rates